Book Holiday Homes in Cape Girardeau

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Featured Holiday Homes in Cape Girardeau

Notting Hill Cottage

Notting Hill Cottage

Alto Pass
Stay at this vacation home in Alto Pass. Enjoy patios, an in-room coffeemaker, and air conditioning. Popular attractions Peachbarn Winery and Von Jakob Winery ...
Notting Hill Cottage
* On the Wine Trail * Hot Tub * Wi-Fi *

* On the Wine Trail * Hot Tub * Wi-Fi *

Alto Pass
Stay at this vacation home in Alto Pass. Enjoy free WiFi, patios, and cable/satellite TV service. Popular attractions Peachbarn Winery and Von Jakob Winery & ...
* On the Wine Trail * Hot Tub * Wi-Fi *
Quaint, Beautiful Home next to SEMO and Hospital

Quaint, Beautiful Home next to SEMO and Hospital

Cape Girardeau
Stay at this vacation home in Cape Girardeau. Enjoy an in-room coffeemaker, in-room fireplaces, and air conditioning. Popular attractions Show Me Center and ...
Quaint, Beautiful Home next to SEMO and Hospital
Save an average of 15% on thousands of hotels when you're signed in
Wine Trail, Cozy Cabin plus hot tub

Wine Trail, Cozy Cabin plus hot tub

Cobden
Stay at this vacation home in Cobden. Enjoy patios, an in-room coffeemaker, and air conditioning. Popular attractions Owl Creek Vineyard and Rustle Hill Winery ...
Wine Trail, Cozy Cabin plus hot tub
Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural

Cobden
Stay at this vacation home in Cobden. Enjoy free WiFi, a garden, and patios. Popular attractions StarView Vineyards and Owl Creek Vineyard are located ...
Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural
* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

Alto Pass
Stay at this vacation home in Alto Pass. Enjoy free WiFi, an in-room coffeemaker, and air conditioning. Popular attractions Peachbarn Winery and Von Jakob Winery ...
* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *
Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck

Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck

Anna
Stay at this vacation home in Anna. Enjoy patios, cable/satellite TV service, and an in-room coffeemaker. Popular attractions Anna City Park and Lincoln Heritage ...
Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

Cape Girardeau
Book a stay at this family-friendly vacation home in Cape Girardeau. Enjoy free WiFi, a water park, and a garden. Popular attractions Isle Casino Cape Girardeau ...
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Cape Girardeau
Stay at this vacation home in Cape Girardeau. Enjoy free WiFi, a water park, and a garden. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Don't see what you're looking for?
See all available properties in Cape Girardeau
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cape Girardeau Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Cape Girardeau vacation homes are the perfect way for you to wing it.

Holiday houses in Cape Girardeau let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Cape Girardeau in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Cape Girardeau adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Cape Girardeau with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Cape Girardeau vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Cape Girardeau Holiday Homes essential information

Accommodation
43 Holiday Homes
Lowest Price
NZ$125
Highest Price
NZ$197
Popular accommodation
Notting Hill Cottage, * On the Wine Trail * Hot Tub * Wi-Fi *, Quaint, Beautiful Home next to SEMO and Hospital, Wine Trail, Cozy Cabin plus hot tub, Minutes from WineTrail, Giant City, Shawnee Forest - Daily Deer Viewing - Rural, * Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *, Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck, "Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau, Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Top trending hotels in Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is NZ$188 per night from 4 Feb to 5 Feb
NZ$188
includes taxes & fees
4 Feb - 5 Feb
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Drury Inn & Suites Cape Girardeau
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

2.5 out of 5
3253 William Street, Cape Girardeau, MO
Fully refundable
The price is NZ$197 per night from 9 Feb to 10 Feb
NZ$197
includes taxes & fees
9 Feb - 10 Feb
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is NZ$125 per night from 18 Feb to 19 Feb
NZ$125
includes taxes & fees
18 Feb - 19 Feb
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Pear Tree Inn Cape Girardeau West
Save an average of 15% on thousands of hotels when you're signed in
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is NZ$197 per night from 4 Feb to 5 Feb
NZ$197
includes taxes & fees
4 Feb - 5 Feb
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Plaza Hotel Cape Girardeau Conference Center
Don't see what you're looking for?
See all available properties in Cape Girardeau
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.