We stayed in a loft apartment and had a wonderful time. The loft was spacious and clean and included a full kitchen with two balconies, one mini (maybe 1m²) and one full. It did not include cleaning during the stay, but you can restock toiletries and towels at the front desk. If you have trouble with stairs, the loft isn't a good choice because the sleeping space and bathroom are upstairs.
The location is within walking distance to several metro and bus stops, Plaza de Armas, Catedral de Santiago, La Moneda, and more. We had no concerns about safety other than the usual issues that any major city has.