I stayed at Il Perseo for 5 nights with my sister and my nieces over Thanksgiving. We could not have been happier with the location, the staff, and the accommodations! It is a very easy 5 minute walk to the stop for the tram to the airport or the entry to the train station. It is a half a block from Il Duomo! The staff are well trained, multi-lingual, and always available. The initial entry was even easier than I had anticipated and we felt safe with the coded gate entrance process for the rest of our stay.
We had two people in each of two rooms, which gave us plenty of space. Bathrooms were clean, and water was warm - or as hot as you like. We used the dining area downstairs when we wanted to play games as a family.
My only suggestion for other travelers is to bring allergy medicine. While the hotel itself is clean, there is a central elevator for the building with a metal grid surrounding it that does not appear to have ever been cleaned. One of my nieces had dust allergy issues whenever we were there.
Overall, I would happily stay here again!