Compare Family Hotels in Southeast Missouri

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in Southeast Missouri

Featured Southeast Missouri Family Hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is NZ$201 per night from 28 Dec to 29 Dec
NZ$201
includes taxes & fees
28 Dec - 29 Dec
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Drury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is NZ$156 per night from 10 Jan to 11 Jan
NZ$156
includes taxes & fees
10 Jan - 11 Jan 2025
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Pear Tree Inn Sikeston
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is NZ$160 per night from 6 Jan to 7 Jan
NZ$160
includes taxes & fees
6 Jan - 7 Jan 2025
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
Best Western Plus Sikeston
Save an average of 15% on thousands of hotels when you're signed in
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is NZ$180 per night from 10 Jan to 11 Jan
NZ$180
includes taxes & fees
10 Jan - 11 Jan 2025
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Drury Inn & Suites Cape Girardeau
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd, Jackson, MO
Fully refundableReserve now, pay when you stay
The price is NZ$178 per night from 6 Jan to 7 Jan
NZ$178
includes taxes & fees
6 Jan - 7 Jan 2025
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
Comfort Suites Jackson-Cape Girardeau
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel

2.5 out of 5
1802 Gamel Cemetery Road, Festus, MO
Fully refundable
The price is NZ$251 per night from 4 Jan to 5 Jan
NZ$251
includes taxes & fees
4 Jan - 5 Jan 2025
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane, Jackson, MO
Fully refundableReserve now, pay when you stay
The price is NZ$168 per night from 29 Dec to 30 Dec
NZ$168
includes taxes & fees
29 Dec - 30 Dec
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Drury Inn & Suites Jackson MO
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84, Hayti, MO
Fully refundableReserve now, pay when you stay
The price is NZ$189 per night from 29 Dec to 30 Dec
NZ$189
includes taxes & fees
29 Dec - 30 Dec
Stay at this 3-star business-friendly hotel in Hayti. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Drury Inn & Suites Hayti Caruthersville
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

2.5 out of 5
3253 William Street, Cape Girardeau, MO
Fully refundable
The price is NZ$198 per night from 12 Jan to 13 Jan
NZ$198
includes taxes & fees
12 Jan - 13 Jan 2025
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Hotels Southeast Missouri

If you need a holiday like The Bachelor needs fancy tropical proposals, but can’t bear to leave the rugrats behind, you’re in luck: There are plenty of hotels for families in Southeast Missouri that are ready to cater to your kiddos. Pack up the fruit snacks and tablets (and don’t forget the headphones, so your teens can ignore you!) and get on the road to family bonding. A break from the ordinary could be just what you need to put the “dear” back in “nearest and dearest.”

Whether you’re embarking on the trip of a lifetime with the extended family or just taking a sickie so you can have a long-weekend escape with your tween, Southeast Missouri family hotels are fun for all ages. Offering things like activity areas, kids’ pools, lessons, child care and more, kid-friendly accommodation options can go the distance to add true relaxation to your bank of new favourite memories. You can easily get off the property, too; check out the action near the city centre, explore the local landmarks and chow down on the best of the best cuisine (no Happy Meals necessary).

You’re busy remembering birthdays and anniversaries, so if you forgot to plan that next family getaway, no worries. lastminute.co.nz has the best deals on family hotels in Southeast Missouri and the widest variety, so finding your match is easier than saying your ABCs. Your trip will be so legendary, no one ever has to know it came down to the wire.

Southeast Missouri hotels essential information

Accommodation
531 hotels
Lowest Price
NZ$156
Highest Price
NZ$251
Popular hotels
Drury Inn & Suites Sikeston, MO, Pear Tree Inn Sikeston, Best Western Plus Sikeston, Drury Inn & Suites Cape Girardeau, Comfort Suites Jackson-Cape Girardeau, Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel, Drury Inn & Suites Jackson MO, Drury Inn & Suites Hayti Caruthersville, Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

Most recent Southeast Missouri hotel reviews

More ways to explore Southeast Missouri