Book Defiance hotels

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in Defiance

Cheap Defiance hotels

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
The price is NZ$232 per night from 24 Feb to 25 Feb
NZ$232
includes taxes & fees
24 Feb - 25 Feb
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
Hollywood Casino & Hotel St. Louis
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl, Wildwood, MO
Fully refundableReserve now, pay when you stay
The price is NZ$186 per night from 24 Feb to 25 Feb
NZ$186
includes taxes & fees
24 Feb - 25 Feb
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
The Wildwood Hotel
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
Fully refundableReserve now, pay when you stay
The price is NZ$391 per night from 24 Feb to 25 Feb
NZ$391
includes taxes & fees
24 Feb - 25 Feb
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
Ameristar Casino Resort and Spa
Save an average of 15% on thousands of hotels when you're signed in
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive, Fenton, MO
Fully refundable
The price is NZ$180 per night from 24 Feb to 25 Feb
NZ$180
includes taxes & fees
24 Feb - 25 Feb
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

2.5 out of 5
1100 S Highway Dr, Fenton, MO
Fully refundableReserve now, pay when you stay
The price is NZ$152 per night from 24 Feb to 25 Feb
NZ$152
includes taxes & fees
24 Feb - 25 Feb
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Wingate by Wyndham St. Louis/Fenton Route 66
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

2.5 out of 5
1970 Craig Rd, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
The price is NZ$120 per night from 27 Feb to 28 Feb
NZ$120
includes taxes & fees
27 Feb - 28 Feb
Stay at this hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Crowne Plaza St. Louis Airport, an IHG Hotel

Crowne Plaza St. Louis Airport, an IHG Hotel

3.5 out of 5
11228 Lone Eagle Dr, Bridgeton, MO
Fully refundable
The price is NZ$275 per night from 28 Feb to 1 Mar
NZ$275
includes taxes & fees
28 Feb - 1 Mar
Stay at this 3.5-star business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Crowne Plaza St. Louis Airport, an IHG Hotel
Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles

3.5 out of 5
2 Convention Center Plz, St. Charles, MO
Fully refundableReserve now, pay when you stay
The price is NZ$262 per night from 2 Mar to 3 Mar
NZ$262
includes taxes & fees
2 Mar - 3 Mar
Stay at this 3.5-star business-friendly hotel in St. Charles. Enjoy free breakfast, free parking, and a free area shuttle. Our guests praise the breakfast and ...
Embassy Suites by Hilton St. Louis St. Charles
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

3 out of 5
15431 Conway Rd, Chesterfield, MO
Fully refundableReserve now, pay when you stay
The price is NZ$188 per night from 2 Mar to 3 Mar
NZ$188
includes taxes & fees
2 Mar - 3 Mar
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Sonesta ES Suites St. Louis - Chesterfield
Don't see what you're looking for?
See all available properties in Defiance
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Defiance

Should you choose to vacation in Defiance, be sure book early, as you won't find a huge range of hotel options in close proximity to Defiance's downtown.

The Holiday Inn St. Louis West Six Flags, Missouri, which is the closest accommodation, sits 20 kilometres from downtown Defiance. Another alternative is the Residence Inn By Marriott St Louis Chesterfield, situated in Missouri, 20 kilometres from Defiance.

10 kilometres away from the main part of Defiance is the Staybridge Suites O'Fallon Chesterfield. The Residence Inn by Marriott O'Fallon is located 10 kilometres away. Some other accommodation options are the Holiday Inn Express St. Louis West - O'Fallon and the Hilton Garden Inn St. Louis/O'Fallon.

Looking to travel further afield? St. Louis - Northeast Missouri offers plenty of other attractions to keep you busy throughout your stay. Spend time at the history museums in St. Louis - Northeast Missouri. You can also make the time to admire its prairies. Or join the locals mountain biking and hiking while you're here.

Looking for more to do? Kick back and spend the day visiting the Hollywood Casino and Westport Plaza, which you'll find in Maryland Heights, 30 kilometres to the east of Defiance. If you'd like to visit Maryland Heights, check out the room rates at the Sheraton Westport Plaza Hotel St. Louis and Hawthorn Suites by Wyndham St. Louis Westport Plaza. Or, you could consider staying in Chesterfield, 16 kilometres to the east of Defiance, where you can pick from the Hampton Inn & Suites St. Louis/Chesterfield and Comfort Inn & Suites St. Louis - Chesterfield. If you're staying in Chesterfield, you might like to visit the Faust Park and Sophia M. Sachs Butterfly House.

If sport gives you a buzz, be sure to take a trip to Scottrade Center, which is 50 kilometres to the east of Defiance. Book a hotel near the action at the Four Seasons Hotel St Louis or the Grand Center Inn.

Visitors transiting through Lambert-St. Louis International Airport might like to book accommodation at the Marriott St. Louis Airport or the Holiday Inn St. Louis-Airport, both of which are close.

Defiance hotels essential information

Accommodation
811 hotels
Lowest Price
NZ$120
Highest Price
NZ$391
Popular hotels
Hollywood Casino & Hotel St. Louis, The Wildwood Hotel, Ameristar Casino Resort and Spa, Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, Wingate by Wyndham St. Louis/Fenton Route 66, Days Inn and Suites by Wyndham St. Louis/Westport Plaza, Crowne Plaza St. Louis Airport, an IHG Hotel, Embassy Suites by Hilton St. Louis St. Charles, Sonesta ES Suites St. Louis - Chesterfield

Most recent Defiance hotel reviews

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.