Book Defiance hotels

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in Defiance

Cheap Defiance hotels

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive, Fenton, MO
Fully refundableReserve now, pay when you stay
The price is NZ$190 per night from 30 Mar to 31 Mar
NZ$190
includes taxes & fees
30 Mar - 31 Mar
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

3 out of 5
15431 Conway Rd, Chesterfield, MO
Fully refundableReserve now, pay when you stay
The price is NZ$188 per night from 1 Apr to 2 Apr
NZ$188
includes taxes & fees
1 Apr - 2 Apr
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Sonesta ES Suites St. Louis - Chesterfield
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
The price is NZ$244 per night from 30 Mar to 31 Mar
NZ$244
includes taxes & fees
30 Mar - 31 Mar
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
Hollywood Casino & Hotel St. Louis
Save an average of 15% on thousands of hotels when you're signed in
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl, Wildwood, MO
Fully refundableReserve now, pay when you stay
The price is NZ$168 per night from 1 Apr to 2 Apr
NZ$168
includes taxes & fees
1 Apr - 2 Apr
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
The Wildwood Hotel
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
Fully refundableReserve now, pay when you stay
The price is NZ$374 per night from 31 Mar to 1 Apr
NZ$374
includes taxes & fees
31 Mar - 1 Apr
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
Ameristar Casino Resort and Spa
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

2.5 out of 5
1100 S Highway Dr, Fenton, MO
Fully refundableReserve now, pay when you stay
The price is NZ$159 per night from 20 Apr to 21 Apr
NZ$159
includes taxes & fees
20 Apr - 21 Apr
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Wingate by Wyndham St. Louis/Fenton Route 66
La Quinta Inn & Suites by Wyndham St. Louis Westport

La Quinta Inn & Suites by Wyndham St. Louis Westport

2.5 out of 5
11805 Lackland Rd, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
The price is NZ$181 per night from 6 Apr to 7 Apr
NZ$181
includes taxes & fees
6 Apr - 7 Apr
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
La Quinta Inn & Suites by Wyndham St. Louis Westport
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

3 out of 5
380 Mulholland Drive, St. Charles, MO
Fully refundableReserve now, pay when you stay
The price is NZ$223 per night from 30 Mar to 31 Mar
NZ$223
includes taxes & fees
30 Mar - 31 Mar
Stay at this 3-star business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Plaza Hotel St. Louis St. Charles
Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport

2.5 out of 5
12220 Dorsett Rd, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
The price is NZ$180 per night from 31 Mar to 1 Apr
NZ$180
includes taxes & fees
31 Mar - 1 Apr
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Best Western Plus St. Louis West-Westport
Don't see what you're looking for?
See all available properties in Defiance
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Defiance

Should you choose to vacation in Defiance, be sure book early, as you won't find a huge range of hotel options in close proximity to Defiance's downtown.

The Holiday Inn St. Louis West Six Flags, Missouri, which is the closest accommodation, sits 20 kilometres from downtown Defiance. Another alternative is the Residence Inn By Marriott St Louis Chesterfield, situated in Missouri, 20 kilometres from Defiance.

10 kilometres away from the main part of Defiance is the Staybridge Suites O'Fallon Chesterfield. The Residence Inn by Marriott O'Fallon is located 10 kilometres away. Some other accommodation options are the Holiday Inn Express St. Louis West - O'Fallon and the Hilton Garden Inn St. Louis/O'Fallon.

Looking to travel further afield? St. Louis - Northeast Missouri offers plenty of other attractions to keep you busy throughout your stay. Spend time at the history museums in St. Louis - Northeast Missouri. You can also make the time to admire its prairies. Or join the locals mountain biking and hiking while you're here.

Looking for more to do? Kick back and spend the day visiting the Hollywood Casino and Westport Plaza, which you'll find in Maryland Heights, 30 kilometres to the east of Defiance. If you'd like to visit Maryland Heights, check out the room rates at the Sheraton Westport Plaza Hotel St. Louis and Hawthorn Suites by Wyndham St. Louis Westport Plaza. Or, you could consider staying in Chesterfield, 16 kilometres to the east of Defiance, where you can pick from the Hampton Inn & Suites St. Louis/Chesterfield and Comfort Inn & Suites St. Louis - Chesterfield. If you're staying in Chesterfield, you might like to visit the Faust Park and Sophia M. Sachs Butterfly House.

If sport gives you a buzz, be sure to take a trip to Scottrade Center, which is 50 kilometres to the east of Defiance. Book a hotel near the action at the Four Seasons Hotel St Louis or the Grand Center Inn.

Visitors transiting through Lambert-St. Louis International Airport might like to book accommodation at the Marriott St. Louis Airport or the Holiday Inn St. Louis-Airport, both of which are close.

Defiance hotels essential information

Accommodation
813 hotels
Lowest Price
NZ$159
Highest Price
NZ$374
Popular hotels
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, Sonesta ES Suites St. Louis - Chesterfield, Hollywood Casino & Hotel St. Louis, The Wildwood Hotel, Ameristar Casino Resort and Spa, Wingate by Wyndham St. Louis/Fenton Route 66, La Quinta Inn & Suites by Wyndham St. Louis Westport, Drury Plaza Hotel St. Louis St. Charles, Best Western Plus St. Louis West-Westport

Most recent Defiance hotel reviews

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.