The St. Regis San Francisco offers 260 accommodations, which are accessible via exterior corridors and feature minibars and laptop-compatible safes. Pillowtop beds feature Frette Italian sheets, down comforters, and premium bedding. 55-inch Smart televisions come with premium cable channels and pay movies. Bathrooms include bathrobes, slippers, designer toiletries, and hair dryers.
In-room wireless Internet access (speed: 25+ Mbps) is available for a surcharge. Business-friendly amenities include desks and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Hypo-allergenic bedding, change of towels, and change of bedsheets can be requested. A nightly turndown service is provided and housekeeping is offered daily.