Book San Diego Santa Fe Depot hotels

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in San Diego Santa Fe Depot

20 Apr - 21 Apr
Tonight
Check prices close to San Diego Santa Fe Depot for tonight, 20 Apr - 21 Apr
21 Apr - 22 Apr
Tomorrow night
Check prices close to San Diego Santa Fe Depot for tomorrow night, 21 Apr - 22 Apr

Cheap San Diego Santa Fe Depot hotels

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$201 per night from 28 Apr to 29 Apr
NZ$201
includes taxes & fees
28 Apr - 29 Apr
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$435 per night from 21 Apr to 22 Apr
NZ$435
includes taxes & fees
21 Apr - 22 Apr
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
San Diego Mission Bay Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$289 per night from 27 Apr to 28 Apr
NZ$289
includes taxes & fees
27 Apr - 28 Apr
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$321 per night from 27 Apr to 28 Apr
NZ$321
includes taxes & fees
27 Apr - 28 Apr
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
The Dana on Mission Bay
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$408 per night from 27 Apr to 28 Apr
NZ$408
includes taxes & fees
27 Apr - 28 Apr
Book a stay at this beach resort in San Diego. Enjoy free parking, a beach locale, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
Bahia Resort Hotel
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$487 per night from 27 Apr to 28 Apr
NZ$487
includes taxes & fees
27 Apr - 28 Apr
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Paradise Point Resort & Spa
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$237 per night from 27 Apr to 28 Apr
NZ$237
includes taxes & fees
27 Apr - 28 Apr
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
Hilton San Diego Mission Valley
Humphreys Half Moon Inn

Humphreys Half Moon Inn

3.5 out of 5
2303 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$323 per night from 21 Apr to 22 Apr
NZ$323
includes taxes & fees
21 Apr - 22 Apr
Book a stay at this business-friendly hotel in San Diego. Enjoy a marina, a nightclub, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Humphreys Half Moon Inn
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$428 per night from 21 Apr to 22 Apr
NZ$428
includes taxes & fees
21 Apr - 22 Apr
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Lafayette Hotel & Club
Don't see what you're looking for?
See all available properties in San Diego Santa Fe Depot
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Santa Fe Depot hotels essential information

Accommodation
3,708 hotels
Lowest Price
NZ$201
Highest Price
NZ$487
Popular hotels
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area , San Diego Mission Bay Resort, Wyndham San Diego Bayside, The Dana on Mission Bay, Bahia Resort Hotel, Paradise Point Resort & Spa, Hilton San Diego Mission Valley, Humphreys Half Moon Inn, Lafayette Hotel & Club

Most recent San Diego Santa Fe Depot hotel reviews

The Dana on Mission Bay
lastminute.co.nz Verified Review
5 / 5
Not enough parking.
A verified traveller from DANVILLE stayed at The Dana on Mission Bay
Posted 10 hours ago
The Dana on Mission Bay

More ways to explore San Diego Santa Fe Depot

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.